Niv Zmora, Gili Zilberman-Schapira, Jotham Suez, Uria Mor, Mally Dori-Bachash, Stavros Bashiardes, Eran Kotler, Maya Zur, Dana Regev-Lehavi, Rotem Ben-Zeev Brik, Sara Federici, Yotam Cohen, Raquel Linevsky, Daphna Rothschild, Andreas E. Moor, Shani Ben-Moshe, Alon Harmelin, Shalev Itzkovitz, Nitsan Maharshak, Oren Shibolet, Hagit Shapiro, Meirav Pevsner-Fischer, Itai Sharon, Zamir Halpern, Eran Segal, Eran Elinav. Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features. Cell, 2018; 174 (6): 1388 DOI: 10.1016/j.cell.2018.08.041
Deep Immune Support Probiotics started with a simple premise: Most probiotic strains present on the market today cannot survive the acidic environment of the human digestive system. Additionally, most of the most powerful probiotics require refrigeration, meaning they won’t survive standard delivery services or even room temperatures during your commute or travel.

Probi is continuously thriving to develop and investigate new possible indications where probiotics may have positive and efficient effects to improve health. We are science-driven, and investigate new possibilities to find the Next Generation Probiotics. This concept involves new bacterial strains that has never before been cultivated and used for health-purposes. 


Self-dosing with bacteria isn't as outlandish as it might seem. An estimated 100 trillion microorganisms representing more than 500 different species inhabit every normal, healthy bowel. These microorganisms (or microflora) generally don't make us sick; most are helpful. Gut-dwelling bacteria keep pathogens (harmful microorganisms) in check, aid digestion and nutrient absorption, and contribute to immune function.
A Seal of Approval When looking for a good probiotic, Gans advises consumers to buy from a trusted retailer and look for a seal from a third-party certifier. “Reputable probiotic supplements should list the genus, species, and strain, in addition to the number of organisms that will be alive by the use-by date and the dose on the label,” says Gans. This transparency will help consumers understand what’s in their supplement and how to best use it.
That’s why adding probiotics and prebiotics to your diet provide the best possible outcome from a bacterial perspective. It isn’t always easy to eat naturally prebiotic-enriched foods, however, because they are often distasteful to eat in quantity. Would you enjoy eating several cups of raw onion or garlic every day? Probably not. Other foods that contain prebiotic fiber, such as bread and bananas, are high in calories. Consuming hundreds of calories of these foods every day is counterproductive if you’re trying to lose weight.
Let’s start at the very beginning: probiotics are bacteria. We know what you’re thinking, bacteria cause infections and are just generally kind of gross. Well, in some aspects, you’re absolutely right. But when it comes to your digestive and feminine health, some bacteria are teeny tiny miracle workers that can make all the difference in the way you feel!
The reason constipation is linked to disease is that it allows undigested food and bodily wastes to sit in the colon, putrefy, and dry out. As feces dry out, water from the feces is reabsorbed back into the body, and along with it toxins. Additionally, microbes that like those conditions can multiply, releasing their toxic products that are then absorbed into your bloodstream.
If you don’t have a specific health goal in mind and want to bolster the number of good bacteria floating around your system, Perlmutter recommends starting with a minimum of eight to 10 different bacterial species. He included a core five (L. Plantarum, L. Acidophilus, L. Brevis, B. Lactis, and B. Longum) and we added five more highly researched and universally beneficial strains for a general health pick. Vita Miracle, formerly Islands Miracle, has nine of those 10, plus 30 billion CFUs per serving.
Probiotics are found in everything from chocolate and pickles to hand lotion and baby formula, and millions of people buy probiotic supplements to boost digestive health. But new research suggests they might not be as effective as we think. Through a series of experiments looking inside the human gut, researchers show that many people's digestive tracts prevent standard probiotics from successfully colonizing them. Furthermore, taking probiotics to counterbalance antibiotics could delay the return of normal gut bacteria and gut gene expression to their naïve state. The research publishes as two back-to-back papers on September 6 in the journal Cell.

Oral health. An increasing number of probiotic lozenges and gums are promoted for oral health—to reduce periodontal disease, throat infections, and bad breath, for example. There’s preliminary evidence that certain strains may have some benefits, but commercial products may not have the same strains and formulations as those tested in published studies.

Some companies have been around for years, and you may know their names. Those that have made probiotics for a while likely have tested and studied them over and over. It's smarter to choose a product from them over one from a maker you don't know. Check a third-party certifier (like ConsumerLab or the USP) to see if they have tested the product and found that it’s safe and reliable. If you're in doubt, ask your doctor.
I didn’t know there was much of a difference between probiotics until I did some research. After realizing the ones I had been getting were probably not doing anything for me, I wanted to invest in a better option. This brand checked all the boxes and was still really affordable! I’ve been taking them for about a week now and I can tell a difference! The first few days I didn’t feel too great but realized it was because this probiotic was actually doing something for me and rebalancing my gut. Now I feel less bloated and all around healthier. I will definitely be getting more!

Lebwohl says IBS isn’t just about intestinal distress. For many IBS sufferers, it’s about the way our brain receives messages about pain. He describes the human colon as “almost reptilian” in the way that it contracts and relaxes throughout the day, but says these contractions are usually happening way below our threshold of consciousness, so we don’t even notice. In people with IBS, the neurotransmitters in our gut (yes, we have them in there too) may be sending severe distress signals to the brain about benign contractions happening in digestive tract.
Once the GI microbiome is disrupted, and especially if an infection is treated with antibiotics, it can take time for the resident microbiota to recover, if it ever does. A disrupted gut microbiome sets the stage for altered motility, intestinal hypersensitivity, gut immune activation, leaky gut, altered bile, mental disorders, and a host of other factors that can play a role in IBS. Good probiotics, along with a proper diet, can help the GI tract get the microbes it needs to function normally.
Unless you have a perfect gut and are already eating lots of fermented foods—which is rare, although you can work up to this point—it’s difficult to get all the probiotics you need from diet alone. Most of us don’t have perfect guts—everything from antibiotics to high-carbohydrate diets to being born via a C-section can compromise the balance of bacteria in our microbiome. Supplementing with a probiotic can help to restore imbalances, and it’s also just a great preventative health measure, helping to keep your microbiome in balance and your immune system healthy to ward off illnesses.
"When certain types of probiotics are placed in contact with skin cells, they calm the parts of the cells that may want to react to the presence of bad bacteria that they see as a threat. These healthy signals produced by the probiotics stop the skin cells from sending 'attack' messages to the immune system that result in flares of acne or rosacea."
The takeaway: Certain strains were found useful in preventing diarrhea among children being prescribed antibiotics. A 2013 review showed that after antibiotic use, probiotics help prevent Clostridium difficile-associated diarrhea. A review focused on acute infectious diarrhea found a benefit, again for certain strains of bacteria at controlled doses. There’s also evidence that they may help prevent necrotizing enterocolitis (a serious gastrointestinal condition) and death in preterm infants.
Evidence from clinical trials is mixed and often of low quality, but findings from meta-analyses suggest that probiotics can provide benefits in the treatment of some conditions, such as infectious and antibiotic-associated diarrhoea. As such, taking probiotics after antibiotic treatment is an increasingly common practice. However, two studies recently reported in Cell question whether taking highly concentrated supplements of so-called good bacteria aids the recovery of normal gut flora.
Consuming probiotics regularly will reduce the risk of this. "The concept is that if we have an unhealthy, unbalanced gut environment, toxins can be released into the bloodstream and cause inflammation throughout the body," Engelman adds. "This shift in gut flora and the subsequent inflammation can cause a flare-up in the skin of those who are predisposed to acne, eczema, or rosacea."
Probiotics are “friendly” bacteria that inhabit your body. Sound strange? These microscopic roommates can be your best buds if you show them a little love. One surefire way to do that is with probiotic supplements. Probiotics support the right ratio of good to bad bacteria in your gut. For bonus points, call on digestive enzymes. These unique blends offer specific nutritional support to assist digestion and nutrient absorption. Your healthy body will quickly appreciate these lifelong friends.
It is well known that people with lactose intolerance can often consume yogurt with few symptoms. This is because the probiotics in yogurt help digest the lactose in the small intestine, before it reaches the colon. In addition, the yogurt starter cultures L. bulgaricus and Streptococcus thermophilus help to break down the lactose. Because of its probiotics, yogurt is a good way for people with lactose intolerance to consume the recommended servings of dairy without experiencing uncomfortable symptoms they may get from other dairy products.
Uncontrolled changes in blood sugar levels or a decreased ability to regulate insulin can have serious effects on your overall health, and since far more men than women are at risk for these changes, these issues are well worth paying attention to.5 Research indicates that regularly taking probiotic supplements containing Lactobacillus and Bifidobacterium can help your body maintain blood sugar levels already within a normal range, whether you're simply at risk for insulin-related challenges or you're already experiencing them.
Candida albicans is the most common species that causes yeast infections, but there are others. It is a normal inhabitant of the gastrointestinal tract and is often found in the female vaginal tract. Candida infections on the skin cause red, itchy rashes that often weep moisture, and in the vagina there is often a cottage-cheese-like discharge in addition to the skin symptoms.
Two dangerous diseases in newborns, necrotizing enterocolitis (NEC) and neonatal sepsis, may meet their match with well-designed probiotic supplements. Both of these conditions are common in premature babies and are most dangerous in low birth weight and very low birth weight infants. Research has confirmed that when a pregnant mother takes high-quality probiotics during pregnancy, her baby is significantly less likely to develop either NEC or sepsis, particularly when the baby is breastfed after birth (and mom is still taking the supplements) and/or when probiotics are added to formula. A probiotic supplement with multiple strains seems to be the most effective in these cases.
Yet that’s how probiotics are often offered. They can be distributed in the United States as food, supplements or drugs. The regulations for each are very different. Most people looking for probiotics don’t see the distinctions. Ideally, the ways in which we use and consume probiotics would conform to the data and evidence that back them up. That rarely happens.
Although most studies have shown few, if any, negative side effects, it is important to keep in mind that research on probiotics is still in a preliminary phase. There may be some risk for people who have certain health conditions. As with any supplement, it is essential that before you begin to take a probiotic supplement, that you speak with your physician first to help to ensure that you will not be putting your health at risk.

In a separate study involving 21 healthy volunteers, also published today in Cell, the same group of researchers found that taking probiotics after treatment with broad spectrum antibiotics may actually delay the return of people's normal gut microbiome. This goes against the idea that probiotics can help "repopulate" people's gut bacteria after antibiotics wipe them out.
How can something as small as a microscopic organism be so important for health? The reason is that there is not just one microbe, nor a handful; there are approximately 1 trillion microbes per gram of feces. Microbes within you are found on your mucous membranes, spanning from your mouth to your anus, from your nasal passages to your lungs, in your urinary tract, and even on your eyes. In fact, in your digestive tract alone, it is calculated that for every cell of yours that is human, there are an equal number of bacterial cells.
Pinning down the exact causes of IBS is difficult because each person has his or her own combination of causes. One cause that is receiving much attention is that of a disrupted microbiome, as there is a strong association between having a gastrointestinal (GI) infection, like food poisoning, and the onset of IBS. Also, the FODMAP diet, and nonabsorbable antibiotics to kill gut microbiota, have provided relief in many patients, further supporting the suspicion of a disrupted microbiome as contributing to IBS.
Bottom line: Probiotics are a promising field of research and may one day be used to treat or help prevent many disorders. But there’s not enough solid evidence to recommend their widespread use. Vague claims that probiotics "support good digestive health" are meaningless. Larger, longer and better studies are needed to test specific strains for specific conditions and to determine the proper doses and regimens. 

Unlike many of the probiotics on the market today for women, Vitamin Bounty’s formula is fermented naturally and encased in a delayed-release capsule for more efficient digestion. Specifically, this capsule helps to protect the micro-organism strains from stomach acid, which can dissolve them before your gut has a chance to absorb all of their healthy goodness. With this Women’s Pro-Daily Probiotic design, you can expect more cultures and, as a result, fewer stomach upsets and feminine health problems!
With Prebiotin, you can easily add prebiotic fiber to your diet without worrying about eating huge amounts of troublesome foods or hunting down hard-to-find ingredients. You also won’t have to worry about loading up on high-calorie foods that can negatively affect any effort to lose weight. Combining Prebiotin prebiotic fiber with a diet enriched with probiotic foods can only help your effort to positively influence the bacterial balance in your lower gut.
Then, study participants were divided into one group that consumed a standard probiotic strain available in commercial supplements and a control group that was given a placebo. After two months of treatment, the researchers found that some people were so-called “resisters” who expelled the gut microbiomes in probiotics; others were identified as “persisters” who successfully colonized the generic probiotic strains in their GI tracts.
Yes! Beneficial yeast is a probiotic, defined as a microorganism that supports human wellness. (Probiotic means “for life.”) Saccharomyces boulardii is a remarkable yeast that can significantly support your whole internal ecosystem. It helps reduce problematic yeasts, such as Candida, and replenishes healthy gut flora.* While many probiotic supplements only deliver friendly bacteria without yeast, Probiotic All-Flora contains 5 billion CFU of beneficial yeast for complete support.

Overall, Align Probiotic is one of the better “daily” probiotics out there.  It’s easy to take, comes in convenient packaging and doesn’t require refrigeration.  And it has some research showing it helps with gas, bloating and constipation, especially in women with IBS.  Lots of things to like about this probiotic!  Read the full review here… or click here to go buy it now!

Taking a probiotic every day is a good way to help prevent getting sick and having to go on antibiotics in the first place. Preventative measures, of course, are preferred. Another that is believed to help is upping your vitamin D intake when your immune system needs a boost. Diet is also huge in terms of preventing sickness. Studies show that you can change your microbiome within hours of adjusting your diet. If you’re not into sauerkraut, even just cutting back on sugar and eating more whole foods can make a difference. 

There are a lot of factors that play a role in how well probiotics survive before it actually hits your system. How long a store keeps the product in storage before selling it, the temperature at which you store the probiotic, the foods you eat the probiotic with, or the medications you take can affect the effectiveness of the probiotic. If you’re buying a product closer to its “Sell By” date, you might not reap the full benefits because that probiotic may not be as strong.

Yeast Infections and Bacterial Vaginosis (BV) – If you’ve ever experienced the discomfort of a yeast infection or BV, then you are probably aware that an overgrowth of bacteria causes these unfortunate episodes. While your reproductive system is supposed to foster a healthy environment for yeast, sometimes these levels can increase causing the pain and discomfort of a yeast infection or bacterial infection. By taking a probiotic that contains prebiotics and feminine health probiotics, you can treat and prevent recurrent symptoms!


I’m 65 years of age. I have been taking acid reflux medication daily for at least 15 years and recently my doctor said my kidneys were declining. I’ve read that acid reflux medications taken over a long period of time, can cause kidney damage. By taking a probiotic, will it help reduce stomach acid, where I may be able to stop taking my acid reflux medication altogether?
Some people prefer probiotic supplements over foods, but Dr. Cresci notes that probiotic foods are a better choice. In particular, fermented foods — like yogurt, kefir (a yogurt-like beverage), kombucha (fermented black tea), sauerkraut (refrigerated, not shelf-stable), kimchi (made from fermented cabbage) and tempeh and miso (made from fermented soybeans) — provide a nourishing environment in which healthful bacteria thrive and release an important byproduct: short-chain fatty acids.
Caution needs to be taken by everyone who chooses to take these supplements, but this is especially true for children, pregnant women, elderly people, and people with compromised immune systems. For people with compromised immune systems due to disease or treatment for a disease (such as cancer chemotherapy), taking probiotics may actually increase one's chances of getting sick. It has been shown that the use of various probiotics for immunocompromised patients or patients with a leaky gut has resulted in infections and sepsis (infection of the bloodstream). One case of bacteremia (bacteria in the bloodstream) was recently found when someone with active severe inflammatory bowel diseases with mucosal disruption was given Lactobacillus GG. Always speak with a doctor before taking any supplement under these circumstances.
In 2019, dietary restrictions have become so mainstream that it is virtually impossible to step into a restaurant without spotting a specialized menu for dairy, gluten, vegan, and vegetarian eaters. The supplement industry is no exception and the majority of high-quality probiotics available on the market today include vegan or vegetarian capsules. Many brands are also gluten-free these days as well, and several are dedicated to keeping their formulas free of dairy, soy, and many other common allergens.

Jotham Suez, Niv Zmora, Gili Zilberman-Schapira, Uria Mor, Mally Dori-Bachash, Stavros Bashiardes, Maya Zur, Dana Regev-Lehavi, Rotem Ben-Zeev Brik, Sara Federici, Max Horn, Yotam Cohen, Andreas E. Moor, David Zeevi, Tal Korem, Eran Kotler, Alon Harmelin, Shalev Itzkovitz, Nitsan Maharshak, Oren Shibolet, Meirav Pevsner-Fischer, Hagit Shapiro, Itai Sharon, Zamir Halpern, Eran Segal, Eran Elinav. "Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT." Cell (First published: September 6, 2018)  DOI: 10.1016/j.cell.2018.08.047
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